Neurobiology of Disease Dysregulation of Glutamine Transporter SNAT1 in Rett Syndrome Microglia: A Mechanism for Mitochondrial Dysfunction and Neurotoxicity
نویسندگان
چکیده
Lee-Way Jin,1,2 Makoto Horiuchi,1 Heike Wulff,3 Xiao-Bo Liu,1 Gino A. Cortopassi,4 Jeffrey D. Erickson,5 and Izumi Maezawa1,2 1Department of Pathology and Laboratory Medicine and 2M.I.N.D. (Medical Investigation of Neurodevelopmental Disorders) Institute, University of California Davis Medical Center, Sacramento, California 95817, Departments of 3Pharmacology and 4Molecular Biosciences, University of California Davis, Davis, California 95618, and 5Neuroscience Center, Louisiana State University Health Science Center, New Orleans, Louisiana 70118
منابع مشابه
Dysregulation of glutamine transporter SNAT1 in Rett syndrome microglia: a mechanism for mitochondrial dysfunction and neurotoxicity.
Rett syndrome (RTT) is an autism spectrum disorder caused by loss-of-function mutations in the gene encoding MeCP2, an epigenetic modulator that binds the methyl CpG dinucleotide in target genes to regulate transcription. Previously, we and others reported a role of microglia in the pathophysiology of RTT. To understand the mechanism of microglia dysfunction in RTT, we identified a MeCP2 target...
متن کاملCurcumin Ameliorates Sodium Valproate Induced Neurotoxicity through Suppressing Oxidative Stress and Preventing Mitochondrial Impairments
Background and purpose: Curcumin is a natural polyphenolic compound in turmeric (Curcuma longa). Curcumin has potent free radical scavenger and antioxidant properties that could significantly reduce oxidative damage. Oxidative stress and mitochondrial dysfunction contribute to valproate sodium induced tissue damage. This study investigated the protective effects of curcumin against valproate so...
متن کاملPeroxisomal Malfunction Caused by Mitochondrial Toxin 3-NP: Protective Role of Oxytocin
Peroxisomes are single membrane cell organelles with a diversity of metabolic functions. Here we studied the peroxisomal dysfunction and oxidative stress after 3-nitropropionic acid (3-NP) induced neurotoxicity and the possible protective effects of oxytocin. Adult male and female rats were subjected to Oxt and/or 3-NP treatment. The antioxidant enzymes, Superoxide dismutase (SOD) and Catalase ...
متن کاملPeroxisomal Malfunction Caused by Mitochondrial Toxin 3-NP: Protective Role of Oxytocin
Peroxisomes are single membrane cell organelles with a diversity of metabolic functions. Here we studied the peroxisomal dysfunction and oxidative stress after 3-nitropropionic acid (3-NP) induced neurotoxicity and the possible protective effects of oxytocin. Adult male and female rats were subjected to Oxt and/or 3-NP treatment. The antioxidant enzymes, Superoxide dismutase (SOD) and Catalase ...
متن کاملBreathing disorders in Rett syndrome: progressive neurochemical dysfunction in the respiratory network after birth.
Disorders of respiratory control are a prominent feature of Rett syndrome (RTT), a severely debilitating condition caused by mutations in the gene encoding methyl-CpG-binding protein 2 (MECP2). RTT patients present with a complex respiratory phenotype that can include periods of hyperventilation, apnea, breath holds terminated by Valsalva maneuvers, forced and deep breathing and apneustic breat...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2015